Richard N Channick Selected Research

macitentan

1/2022	Long-Term Safety, Tolerability and Survival in Patients with Pulmonary Arterial Hypertension Treated with Macitentan: Results from the SERAPHIN Open-Label Extension.
1/2019	Safety and tolerability of macitentan in the management of pulmonary arterial hypertension: an update.
10/2018	Psychometric Validation of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire: Results of the SYMPHONY Trial.
1/2018	Pulmonary Arterial Hypertension-Related Morbidity Is Prognostic for Mortality.
1/2018	Association between six-minute walk distance and long-term outcomes in patients with pulmonary arterial hypertension: Data from the randomized SERAPHIN trial.
1/2017	Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial.
1/2017	SERAPHIN haemodynamic substudy: the effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension.
12/2015	Incident and prevalent cohorts with pulmonary arterial hypertension: insight from SERAPHIN.
11/2015	Development of macitentan for the treatment of pulmonary arterial hypertension.
1/2015	Effect of macitentan on hospitalizations: results from the SERAPHIN trial.

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Richard N Channick Research Topics

Disease

42	Pulmonary Arterial Hypertension 01/2022 - 07/2003
17	Pulmonary Hypertension 11/2021 - 01/2004
6	Disease Progression 11/2021 - 02/2013
4	Vascular Remodeling 10/2021 - 08/2005
4	Familial Primary Pulmonary Hypertension 04/2013 - 12/2006
3	Hypertension (High Blood Pressure) 06/2019 - 12/2016
3	Headache (Headaches) 08/2013 - 12/2011
2	Pulmonary Embolism 07/2020 - 07/2003
2	Congenital Heart Defects (Congenital Heart Defect) 01/2019 - 01/2009
2	End Stage Liver Disease 01/2017 - 07/2015
2	Liver Diseases (Liver Disease) 01/2017 - 12/2016
2	Cough 02/2013 - 12/2011
2	Nausea 02/2013 - 12/2011
1	Chronic Obstructive Pulmonary Disease (COPD) 11/2021
1	Thrombophilia 11/2021
1	Neoplasms (Cancer) 11/2021
1	Right Ventricular Dysfunction 04/2021
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 04/2021
1	Hypoxia (Hypoxemia) 01/2021
1	Venous Thromboembolism 07/2020
1	Thrombosis (Thrombus) 01/2020
1	Portal Hypertension 12/2016
1	Atrial Fibrillation 10/2013
1	Chronic Renal Insufficiency 10/2013
1	Chronic Kidney Failure (Chronic Renal Failure) 10/2013
1	Anemia 08/2013
1	Nasopharyngitis 08/2013
1	Inflammation (Inflammations) 06/2012
1	Systemic Scleroderma (Systemic Sclerosis) 02/2012
1	Lung Injury 01/2012
1	Pain (Aches) 12/2011
1	Chest Pain (Chest Pains) 12/2011
1	Vomiting 12/2011
1	Connective Tissue Diseases (Connective Tissue Disease) 01/2009
1	Thrombocytopenia (Thrombopenia) 01/2009
1	Vascular Diseases (Vascular Disease) 06/2004
1	Hypothermia 11/2003

Drug/Important Bio-Agent (IBA)

12	macitentanIBA 01/2022 - 08/2013
10	Epoprostenol (Prostacyclin)FDA LinkGeneric 04/2021 - 10/2003
8	Endothelin Receptor AntagonistsIBA 01/2019 - 07/2003
5	Bosentan (Tracleer)FDA Link 08/2015 - 07/2003
5	treprostinil FDA Link 02/2013 - 10/2006
4	selexipagIBA 01/2021 - 01/2018
3	Pharmaceutical PreparationsIBA 10/2021 - 12/2006
3	Endothelins (Endothelin)IBA 01/2019 - 06/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 03/2006
3	Sildenafil Citrate (Viagra)FDA Link 08/2015 - 03/2006
3	Brain Natriuretic Peptide (Natrecor)FDA Link 04/2013 - 09/2007
3	Iloprost (Ventavis)FDA Link 04/2013 - 12/2006
2	Epoprostenol ReceptorsIBA 01/2021 - 01/2018
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2013
2	pro-brain natriuretic peptide (1-76)IBA 01/2017 - 04/2013
2	Biomarkers (Surrogate Marker)IBA 12/2016 - 04/2013
2	riociguatIBA 08/2015 - 09/2014
2	ProstaglandinsIBA 08/2013 - 12/2011
2	FenfluramineIBA 01/2009 - 12/2006
1	Blood Group Antigens (Blood Groups)IBA 11/2021
1	DiureticsIBA 11/2021
1	Oxygen (Dioxygen)IBA 11/2021
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 10/2021
1	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA 10/2021
1	Macrophage Colony-Stimulating FactorIBA 10/2021
1	Phosphotransferases (Kinase)IBA 10/2021
1	Adenosine Diphosphate (ADP)IBA 01/2021
1	Macrophage Migration-Inhibitory FactorsIBA 12/2016
1	Vasodilator Agents (Vasodilators)IBA 12/2015
1	hydralazine 4-anisaldehyde hydrazoneIBA 04/2013
1	EndoglinIBA 04/2013
1	C-Reactive ProteinIBA 04/2013
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 04/2013
1	7-(N-(3-aminopropyl)amino)heptan-2-oneIBA 02/2012
1	CytokinesIBA 01/2012
1	SteroidsIBA 01/2012
1	Methylprednisolone FDA LinkGeneric 01/2012
1	TRPC6 Cation ChannelIBA 05/2009
1	Amphetamine (Amfetamine)FDA LinkGeneric 12/2006
1	Cocaine (Cocaine HCl)IBA 12/2006
1	Methamphetamine (Desoxyn)FDA LinkGeneric 12/2006
1	Cyclic GMPIBA 03/2006
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 03/2006
1	Endothelin-1 (Endothelin 1)IBA 08/2005
1	Vasoconstrictor AgentsIBA 08/2005
1	Endothelin Receptors (Endothelin Receptor)IBA 06/2004
1	Neurotransmitter Agents (Neurotransmitter)IBA 07/2003

Therapy/Procedure

23	Therapeutics 11/2021 - 10/2003
5	Endarterectomy (Thromboendarterectomy) 12/2017 - 01/2004
3	Transplantation 01/2017 - 07/2004
2	Liver Transplantation 06/2019 - 07/2015
1	Vena Cava Filters (Inferior Vena Cava Filter) 07/2020
1	Thrombectomy 01/2020
1	Radiofrequency Ablation 10/2013
1	Kidney Transplantation 10/2013
1	Lung Transplantation 08/2013
1	Sternotomy 11/2003
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 11/2003
1	Duration of Therapy 10/2003